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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Ocidental. |
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Data corrente: |
16/10/2023 |
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Data da última atualização: |
16/10/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CHURA, S. S. D.; MEMÓRIA, K. A. S.; LOPES, A. T.; PELISSARI, F. M.; SILVEIRA, J. V. W. da; BEZERRA, J. de A.; CHAVES, F. C. M.; RODRIGUES, A. P.; FARIA, J. A. Q. A.; CARNEIRO, G. |
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Afiliação: |
SOFIA SANTOS DONAIRE CHURA, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; KATHELEN ANNE SUDO MEMÓRIA, UNIVERSIDADE FEDERAL DO AMAZONAS; AMANDA TIBÃES LOPES, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; FRANCIELE MARIA PELISSARI, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; JOÃO VINÍCIOS WIRBITZKI DA SILVEIRA, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; JAQUELINE DE ARAÚJO BEZERRA, FEDERAL INSTITUTE OF EDUCATION, SCIENCE AND TECHNOLOGY OF AMAZONAS; FRANCISCO CELIO MAIA CHAVES, CPAA; ANA PAULA RODRIGUES, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; JERUSA ARAÚJO QUINTÃO ARANTES FARIA, UNIVERSIDADE FEDERAL DO AMAZONAS; GUILHERME CARNEIRO, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS. |
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Título: |
Red sacaca essential oil-loaded nanostructured lipid carriers optimized by factorial design: cytotoxicity and cellular reactive oxygen species levels. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Frontiers in Pharmacology, v. 14, art. 1176629, 2023. |
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DOI: |
https://doi.org/10.3389/fphar.2023.1176629 |
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Idioma: |
Inglês |
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Conteúdo: |
Amazonian flora includes several species with the potential to develop pharmaceutical and biotechnological products. The essential oils from Amazonian species possess some biological properties, such as antioxidant, antibacterial, and cytotoxic activities. The essential oil of red sacaca (RSO), Croton cajucara Benth., contains metabolites characterized by antioxidant and anti-inflammatory activities. Nanostructured lipid carriers (NLC) are an advantageous alternative for the effective delivery of drugs because they can solubilize lipophilic actives and reduce their cytotoxicity. This study aimed to optimize the synthesis of RSO-loaded nanostructured lipid carriers (NLC-RSO) using a 23 factorial design and investigate their antioxidant and cytotoxic effects. The red sacaca essential oil (RSO) metabolite profile was characterized using gas chromatography coupled with a mass spectrometer (GC-MS), identifying 33 metabolites, with linalool and 7-hydroxy-calamenene as the major ones, as reported in the literature. |
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Palavras-Chave: |
Amazon plants; Nanotecnologia; Plant metabolites; Rotational central composite design; Sacaca. |
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Thesaurus Nal: |
Croton cajucara; Nanotechnology. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1157230/1/fphar-14-1176629.pdf
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Marc: |
LEADER 02071naa a2200325 a 4500
001 2157230
005 2023-10-16
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3389/fphar.2023.1176629$2DOI
100 1 $aCHURA, S. S. D.
245 $aRed sacaca essential oil-loaded nanostructured lipid carriers optimized by factorial design$bcytotoxicity and cellular reactive oxygen species levels.$h[electronic resource]
260 $c2023
520 $aAmazonian flora includes several species with the potential to develop pharmaceutical and biotechnological products. The essential oils from Amazonian species possess some biological properties, such as antioxidant, antibacterial, and cytotoxic activities. The essential oil of red sacaca (RSO), Croton cajucara Benth., contains metabolites characterized by antioxidant and anti-inflammatory activities. Nanostructured lipid carriers (NLC) are an advantageous alternative for the effective delivery of drugs because they can solubilize lipophilic actives and reduce their cytotoxicity. This study aimed to optimize the synthesis of RSO-loaded nanostructured lipid carriers (NLC-RSO) using a 23 factorial design and investigate their antioxidant and cytotoxic effects. The red sacaca essential oil (RSO) metabolite profile was characterized using gas chromatography coupled with a mass spectrometer (GC-MS), identifying 33 metabolites, with linalool and 7-hydroxy-calamenene as the major ones, as reported in the literature.
650 $aCroton cajucara
650 $aNanotechnology
653 $aAmazon plants
653 $aNanotecnologia
653 $aPlant metabolites
653 $aRotational central composite design
653 $aSacaca
700 1 $aMEMÓRIA, K. A. S.
700 1 $aLOPES, A. T.
700 1 $aPELISSARI, F. M.
700 1 $aSILVEIRA, J. V. W. da
700 1 $aBEZERRA, J. de A.
700 1 $aCHAVES, F. C. M.
700 1 $aRODRIGUES, A. P.
700 1 $aFARIA, J. A. Q. A.
700 1 $aCARNEIRO, G.
773 $tFrontiers in Pharmacology$gv. 14, art. 1176629, 2023.
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Registro original: |
Embrapa Amazônia Ocidental (CPAA) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
06/02/2017 |
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Data da última atualização: |
06/02/2017 |
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Autoria: |
BOMFIM, M. A. D.; GUIMARAES, V. P.; FACO, O. |
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Afiliação: |
MARCO AURELIO DELMONDES BOMFIM, CNPC; VINICIUS PEREIRA GUIMARAES, CNPC; OLIVARDO FACO, CNPC. |
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Título: |
Ambiente institucional e organizacional; A Embrapa Caprinos e Ovinos. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
In: SORIO, A.; MAGALHÃES, L. A.; MARQUES, W. A. Carne ovina: o ontem, o hoje e o amanhã. Brasília, DF: Escola Superior do Agronegócio Internacional, 2016. p. 165-172. |
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Idioma: |
Português |
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Palavras-Chave: |
Embrapa Caprinos e Ovinos. |
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Thesagro: |
Instituição de Pesquisa. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 00591naa a2200157 a 4500
001 2062861
005 2017-02-06
008 2016 bl uuuu u00u1 u #d
100 1 $aBOMFIM, M. A. D.
245 $aAmbiente institucional e organizacional; A Embrapa Caprinos e Ovinos.
260 $c2016
650 $aInstituição de Pesquisa
653 $aEmbrapa Caprinos e Ovinos
700 1 $aGUIMARAES, V. P.
700 1 $aFACO, O.
773 $tIn: SORIO, A.; MAGALHÃES, L. A.; MARQUES, W. A. Carne ovina: o ontem, o hoje e o amanhã. Brasília, DF: Escola Superior do Agronegócio Internacional, 2016. p. 165-172.
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Embrapa Caprinos e Ovinos (CNPC) |
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